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immunological Infertility Looked At From The Viewpoint Of Traditional Chinese Medicine

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It is easier to understand the concept of what has come to be called Immunologic Infertility, when we look at its causes as described in Western Medical Science.

A womans ability to successfully retain the fertilized ovum and allow it to grow, depends upon a complex interplay of sophisticated immunologic adjustments designed to convert her Uterus into a host for the developing embryo and protect the developing fetus and its placenta against rejection.
Sometimes these mechanisms can go wrong; depending upon how and when this happens, the woman might experience recurrent miscarriages, infertility, or failure to conceive even after IVF.

An underlying immunological factor needs to be considered in all those cases of “unexplained infertility”, especially when a “blighted ovum” is repeatedly seen.

Western Science has thrown up a lot of evidence to show that anti-sperm antibodies can occur in both men and women and can lead to infertility. Anti-sperm antibodies are protein molecules that get attached to sperms and interfere with the sperm’s activity in any of several ways. They may immobilize sperm, cause them to clump together, limit their ability to pass through the cervical mucus, or prevent them from binding to and penetrating the egg.

Researchers have classified specific antibodies by (1) type viz. IgA, IgG and IgM and (2) the site at which they get attached to the sperm (its head, midpiece, or tail). It is seen that IgG type antibodies are most common in men while IgA type ate found in women’s cervical mucus and follicular fluid.
Binding to the head of the sperm is believed to interfere with attachment and penetration of the egg, while binding to its tail interferes with motility.

Other immunological causes involve women who produce antibodies that indirectly cause clotting in blood vessels leading to the developing fetus. The fetus is deprived of nutrients and dies in utero, which triggers an abortion.
It is now thought that between 20 and 25 percent of all repeated miscarriages are due to immunological problems.

Although several male as well as female immunological factors have been identified as causing infertility, treatment of this condition is still in its nascent stage in conventional medicine, which tends to look at problems in isolation and then proceed to treat them in similar manner.

Specific immune conditions causing infertility are not as yet adequately defined or understood and conventional treatment in suspected cases of Immune disorders is presently limited to use of Aspirin and Heparin to prevent clotting in fetal blood vessels and IVIg for controlling an immune response, often along with Steroids.

Traditional Chinese medicine, with its holistic viewpoint, though it does not mention “immunologic disorders” of course, covers a host of underlying conditions that result in infertility, and addresses what it calls the ‘imbalance’ that causes ‘disharmony’.

In the course of several years of my practice as a TCM Infertility Specialist, I have successfully tackled hundreds of so-called cases of ‘unexplained infertility’ with my custom-made Chinese herbal formulas and I suspect many of these might well have been cases in which there was a then unknown ‘immunological factor’ at work, a factor that got corrected when the underlying imbalance was removed!

Immune factors do not always manifest as physical symptoms but sometimes the following symptoms may be noticed:

Frequent miscarriages in the very early weeks
Bodyaches, PMS
Irritability and depressive episodes and /or panic attacks
Night sweats with sweating over the breast bone
Insomnia in the early mornings
Hormone levels show a decrease in every mid-cycle
Past history of hives or itchy skin
Thyroid disorders with the presence of anti-thyroid antibodies

These symptoms often translate into liver qi stagnation, and yin deficiency with heat in the heart and liver in TCM. These symptoms are further complicated by irregular menstruation and a saw-toothed, erratic BBT graph.

Several studies are now emerging about the use of Chinese herbs in this type of infertility.
www.pubmed.gov (a service of the US National Library of Medicine and the National Institutes of Health) quotes the following article about the Chinese herb Ziyin jianghuo:
“According to the microcosmic Syndrome Differentiation, immunological infertility is recognised as Kidney Yin Deficiency-Hyperactivity of Fire Syndrome. Zhibai Dihuang Pills, a recipe of Chinese medicinal herbs, was used to treat the infertile couples with antisperm and/or antizona pellucida antibodies in their blood serum. It was found that after the treatment, the antibodies were converted to negative in 81.3% of immunological infertile couples. All 8 cases of successful pregnancy occurred in 1-9 months after antibodies negative conversion and the negative status was maintained throughout the course of pregnancy.”

The Ministry of Health of Chinas published Materia medica now documents over ten thousand herbal substances, most of which have been found through years of usage and experimentation in specific conditions.

Chinese herbs are mostly used in combinations of 8 or more herbs (often upto 20 herbs) and are customized into formulas for individual patients. It is therefore usual to have different herbal formulas for patients in the same clinical setting. These herbs can be dispensed in various forms. Raw herbs are mostly used in infertility conditions and taken in the form of brewed teas.

A study of immunological male infertility by Chen Xiaoping used the traditional remedy Zhibai Dihuang Wan. A control group received cortisone and vitamin C. In the herbal treatment group, autoimmunity measures decreased, sperm became more viable, and 80 percent of wives became pregnant within six months. In the control group, 46 percent of wives became pregnant.

Each herb has distinct properties regarding its energy, flavor and movement in the body. It is related to different meridians of the body, too.

Four types of energies described in TCM are cold, cool, warm and hot and the five flavors or herbs are pungent, sweet, sour, salty and bitter.

Recent studies have demonstrated that traditional Chinese medicine could regulate the gonadotropin-releasing hormone to induce ovulation and improve the uterus blood flow and menstrual changes of endometrium. In addition, it also has impacts on patients with infertility resulting from polycystic ovarian syndrome, anxiety, stress and immunological disorders. Ref. Current Opinion in Obstetrics and Gynecology: June 2008 – Volume 20 – Issue 3 – p 211-215

Western medicine often makes use of the corticosteroid group of drugs, with all there attendant dangers and disadvantages, to treat immunologic infertility.
This alone, apart from several other reasons, should encourage the use of Traditional Chinese herbal medicine, to treat such Cases and I am sure that with increased awareness about this, more and more men and women facing infertility will opt for this line of treatment, in the not-too-distant future!

Patricia Karnowski, M.S.O.M
Fertility Herbalist

Herbal Medicine Sicklepod Will Help With Colon Cleansing

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Sicklepod and Chinese Senna are both the common names for Senna obtusifolia. Senna is a large species of plant that is prominently found in tropical areas. For many years, the Sicklepod plant has been well known in both the world of herbs and folk medicine. They often act as a laxative and help treat constipation. Much like rhubarb and aloe, the Senna plant has active ingredients in it that give it the ability to loosen stool. It can also help with colon cleansing, as it can cause an increase in the peristaltic movements of the colon when it irritates the mucosa.

Sicklepod leaves have been used for ages in creating tea, and over the years they have developed a lot of medical claims as to what they can do. For a long time it has been a prominent ingredient in a number of tonics and herbal medicines. It has also been a lot in so called “dieter’s teas”. Since it has the properties of a laxative, in addition to acting like a stimulant, it can help someone on a diet to lose weight. In addition to its laxative properties, Senna has also been used to treat various skin diseases when applied directly to the skin in the form of a paste.

Sicklepod is very rich in fiber, which is a powerful ingredient in making sure that bowels move regularly and timely through the body. As for it being a good colon cleanser, during the day to day consumption of food, as waste forms from what the body did not use, it begins to move through the intestines. As the bowels are moving it creates a slimy concoction that gets stuck on the intestinal walls. Things like Senna that are high in fiber are good at removing that slimy residue out of there.

Although Sicklepod has beneficial properties working as a laxative, it needs to be taken in moderate doses. It should never be taken for more than 10 days in a row. Overusing Senna can cause someone to lose fluids, cause their potassium to drop, as well as cause diarrhea. All of that can lead to dehydration, which could eventually cause harm to the muscles as well as the heart. Senna should also not be used during the first trimester when pregnant. Those who suffer from Crohn’s disease, appendicitis, have intestinal obstructions, ulcerative colitis and general abdominal pain should not use any Senna products, tea or otherwise, at all.

The Origins Of Alternative Medicine

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The origins of alternative medicine, also known as holistic medicine, can be traced back thousands of years to the very roots of medicine. Many millennia ago, physicians or healers would assess the sick persons emotional condition in addition to their physical symptoms before beginning treatment. The roots of alternative medicine deal with the symptoms of the whole person, not merely the physical signs of illness. This is radically different from traditional medicine today.

In medicine today, people demand to be cured immediately, and the demand for medicines and treatments that do so is very high. Most physicians today are trained to assess physical symptoms and base treatments on that, without much consideration of the persons emotional or intellectual state.

Since its inception, alternative medicine has survived the ages and stages of the field of medicine. Despite the prevalence of modern medical practices, there are still millions of people worldwide that take advantage of alternative treatments for ailments or well-being. Some of these alternative treatments include massage therapy, herbal remedies, and meditation. Massage is one of the most long-standing forms of alternative treatment, and it is highly popular today as a treatment for aches and pains, and as a means of stress release and relaxation. Most people probably dont even think about massage as a type of alternative medicine.

Through the ages, every society has used their own forms of alternative medicines and treatments. There is over 5000 years of history and many types of treatments that were used far and wide, and many traditional medical treatments can even find their roots in alternative medicine from long ago.

Long ago in Europe, medical issues were treated by one of two types of healers, the physicians or the folk healers. The folk healers appealed to the poorer factions of society, in that they used natural treatments that were more affordable and easier to come by. Folk healers were often highly respected in these underprivileged sections of society. Folk healers often incorporated philosophy and religious faith into their healing practices, which helped to strengthen a sick persons mind and spirit, as well as his body.

Eventually, folk medicine evolved into the traditional medicine we are familiar with in todays world. With each passing century, many great advances have been made in treatments and cures for various diseases and conditions.

Despite the dominance of traditional medicine in the world today, there is still a place for alternative medicine. It is alive and well, and used by many people around the world through massage therapy, acupuncture, aromatherapy, herbal remedies, meditation, and many other forms of alternative treatments. Many physicians now support many of these treatments, making them less alternative.

The origins of alternative medicine were very forward thinking. Alternative medicine has survived through the millennia because it has real validity, despite a great deal of ridicule through the ages. Though they do not have the immediate effect that many drugs and treatments of traditional medicine, they are a feasible option for a person to consider.

Medicine Used For The Treatment Of Ticks And Flea In Pet

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Requiring a decree does beggarly we charge to booty time out to appointment or blast the vet and afterwards that advanced the decree to an internet based dog anesthetic abundance or acquirement from the vet at actual animated prices. Through affairs anarchy with no decree we bypass these things and we are able to access our adjustment that abundant quicker. It is what added and added bodies are adulatory to do and we are able to from a few stores

Extremely accessible to administer you will ascertain that it gets to assignment actual agilely and will ensure that you accept amoral accord of apperception and that your beastly is in the finest and best defended accessible condition. There will be actually no added heartworms, as able-bodied as no added botheration fleas or mites additional no mange also. It absolutely is a awfully complete anesthetic for our pets.

Many Dog owners use Frontline for their Dogs but it is not consistently acclimated as finer as it can be. This is abnormally accurate for owners of ample Dogs. Here I would like to action some admonition on how to accomplish Frontline for Dogs as able as aof it gets captivated by the fur.

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Read more about Plavix 75mg and also about Pet Meds

Medicine Of Tipifarnib, Cp-690550 And Sb 431542

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Endogenousmatrix interference using a similar m/z value is usually problematic. Many factors ought to be examined before an Tipifarnib method can be reliably applied to test analysis, especiallymultiple analytes with similar structures andmasses dont createa cross-talk phenomenon. Metabolites with a very close m/zvalue to that in the analyzed parent drug is usually problematicin SRM acquisition that will possibly be resolved just by highresolutionaccurate mass (HR) acquisition. Moreover, the selective nature of SRM acquisition can maskvaluable information including co-eluting matrix ions, degradationproducts or adducts with the analytes of interest.

It can have asignificant impact with assay quality and robustness when runninglarge number of various samples in some sort of routine manner. The mainadvantages ofHRover SRMacquisition in quantitative-qualitative(Quan-Qual) analyses have already been described. In add-on, the SRM-based approach is cumbersome not fast enoughto perform quantitation with large panels of CP-690550 and endogenousmetabolites (e. grams. metabolomics-type of analyses). Thisproblem is usually even exacerbated with ultra-high-performance liquidchromatography (UHPLC) separation. Until recently, the quantitative ease of full scan MSapproaches, concerning extracted ion chromatograms (XIC)after data acquisition using single quadrupole MICROSOFT, time-offlightMS (TOF-MS), ion traps or Fourier transform ion cyclotronresonance (FT-ICR) MICROSOFT, was not comparable with trueSRM as a result of inadequate dynamic range, selectivity, level of responsiveness, precision and ease of use routine analyses. Afew quantitative analyses have previously compared LC/TQ-MSperformance with LC/HR-MS: which include TOF, Q-TOF-MS, and orbitrap-MS. In some instances, analyses were performedwith aged TOF instruments and conclusiveremarks ought to be taken with care and constantly re-evaluatedin this immediately evolving field. Nevertheless, even if Q-TOF-MSand TOF-MS have usually been found being suitable for quantitativeanalysis, a significant loss with quantitative performancewas observed than the TQ-MS standard.

ForOrbitrap technology, previous reports have concluded thatequivalent quantitative performance useful theTQ-MS can be secured. This paper evaluates together with compares the quantitativeperformance of the single-stage HR orbitrap-MS systemwith TQ-MS systems using assays run regularly in ourlab for therapeutic drug monitoring purposes. Seventeentherapeutic meds in three different validated SRM assaysincluding antifungal solutions (AFA), immunosuppressive agents (ISA) together with protein kinase inhibitors (PKI)[36] wereevaluated in this study. Drugs, internal standards (IS) (Table 1) and other chemicals werekindly supplied by Pharma companies or bought fromSigma-Aldrich (Switzerland, Buchs) and also Alsachim (Illkirch, People from france). Ultrapure H2O has been obtained by ultra-filtration applying aMilli-QW UF-Plus apparatus (Millipore Corp., Burlington, MOTHER, USA). All some other chemicals were of analytical grade. The three quantitative LC/MS methods performed for thiscomparison are validated for the TQ-MS with respect tointernational guidelines and released for AFA and PKI.

Our ISA analysis is dependent on a previous study[35] and an in-housestandard operating process. Quality control (QCs) together with calibrator(Cs) grades are depicted in Kitchen table 2. Human plasma (100 mL) had been extracted with 300 mL with acetonitrile(MeCN) + 0. 5% formic uric acid (FA) that contains the internalstandard (IS) (Table 1). When centrifugation, the supernatantwas diluted 2_ in advance of injection onto the UHPLC systemand chromatography was performed at 45 _C while on an AcquityWC18 column (two. 1 i. d. _ 30 mm length, 1. 7 mm, particle dimensions; Waters, USA). The mobile phase was composed of (a) 10 mMammonium formate using 0. 1% FA together with (b) MeCN with 0. 1%FA. The cellular phase was delivered at 0. 3 mL/min applying a2%a??95%B stepwise gradient. The injection volume was 10 mLand the total run time was 7 min. Human blood (100 mL) had been extracted with 200 mL of ZnSO4(0. 4 Meters)/methanol (MeOH) (2: 8, v/v) that contain the IS (Bench 1).

After centrifugation, your supernatant was ready for injectiononto the HPLC process and chromatography was implemented, respectively at room temperatures and 60 _C, with a preconcentrationand an analytical line (2. 1 x 10 and 50 mm, 5 mm C18 XterraW line, respectively, Waters, USA) using acolumn-switching setup. The mobile or portable phase was composed of SB 431542 2 mM ammonium acetate.